Publication: Plasmodium P36 determines host cell receptor usage during sporozoite invasion
Issued Date
2017-05-16
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ISSN
2050084X
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2-s2.0-85021137667
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Mahidol University
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SCOPUS
Bibliographic Citation
eLife. Vol.6, (2017)
Suggested Citation
Giulia Manzoni, Carine Marinach, Selma Topçu, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean François Franetich, Mirjam B. Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, François Nosten, Thomas F. Baumert, Olivier Silvie Plasmodium P36 determines host cell receptor usage during sporozoite invasion. eLife. Vol.6, (2017). doi:10.7554/eLife.25903 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41902
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Title
Plasmodium P36 determines host cell receptor usage during sporozoite invasion
Abstract
© Manzoni et al. Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocytes remain poorly understood. Here we show that the two main species causing malaria in humans, Plasmodium falciparum and Plasmodium vivax, rely on two distinct host cell surface proteins, CD81 and the Scavenger Receptor BI (SR-BI), respectively, to infect hepatocytes. By contrast, CD81 and SR-BI fulfil redundant functions during infection by the rodent parasite P. berghei. Genetic analysis of sporozoite factors reveals the 6-cysteine domain protein P36 as a major parasite determinant of host cell receptor usage. Our data provide molecular insights into the invasion pathways used by different malaria parasites to infect hepatocytes, and establish a functional link between a sporozoite putative ligand and host cell receptors.