Hormone and Metabolic Research. Vol.14, No.4 (1982), 207-209
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S. Phornchirasilp, O. P. Matangkasombut Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat. Hormone and Metabolic Research. Vol.14, No.4 (1982), 207-209. doi:10.1055/s-2007-1018970 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30300
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Role of adrenal steroids on the cardiac c-AMP response to isoprenaline in the rat
The effect of adrenalectomy on the basal cardiac c-AMP level and the elevated c-AMP level induced by intravenous administration of isoprenaline (10 mcg/kg) were determined by radio-protein assay. The basal cardiac c-AMP level was not altered by adrenalectomy. But the cardiac c-AMP responses to isoprenaline were significantly less in adrenalectomized rats, maintained with 1% sodium chloride solution for one week; this effect, however, disappeared when animals were maintained for 2 or 4 weeks. This could not be restored by acute administration of dexamethasone (100 mcg/rat). The possible reasons for these effects of adrenalectomy are discussed.
