Publication: Development of γ-oryzanol rich extract from leum pua glutinous rice bran loaded nanostructured lipid carriers for topical delivery
Issued Date
2018-01-01
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ISSN
13473352
13458957
13458957
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2-s2.0-85041397181
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Oleo Science. Vol.67, No.2 (2018), 125-133
Suggested Citation
Warangkana Pornputtapitak, Jaturavit Pantakitcharoenkul, Ratchada Panpakdee, Veerawat Teeranachaideekul, Nuttanan Sinchaipanid Development of γ-oryzanol rich extract from leum pua glutinous rice bran loaded nanostructured lipid carriers for topical delivery. Journal of Oleo Science. Vol.67, No.2 (2018), 125-133. doi:10.5650/jos.ess17113 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45444
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Title
Development of γ-oryzanol rich extract from leum pua glutinous rice bran loaded nanostructured lipid carriers for topical delivery
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Abstract
© 2018 by Japan Oil Chemists’ Society. Leum Pua is native Thai glutinous rice that contains antioxidants higher than white rice and other colored rice. One of the major antioxidants in rice brans is γ-oryzanol (GO). In this study, Leum Pua glutinous rice bran was extracted by different solvents. Oleic acid (~40 g/100 g extract), linoleic acid (~30 g/100 g extract), and palmitic acid (~20 g/100 g extract) were found to be major lipid components in the extracts. Methanol extract showed less variety of lipid components compared to the others. However, hexane extract showed the highest percent of γ-oryzanol compared to other solvents. Therefore, the hexane extract was selected to prepare nanostructured lipid carriers (NLC). The prepared NLC had small particles in the size range of 142.9 ± 0.4 nm for extract-loaded NLC and 137.1 ± 0.5 nm for GO-loaded NLC with narrow size distribution (PI < 0.1) in both formulations. The release profile of extract-loaded NLC formulation was slightly higher than GO-loaded NLC formulation. However, they did not follow the Higuchi model because of small amounts of γ-oryzanol loaded in NLC particles.