Publication: Antimalarial activity of biflavonoids from Ochna integerrima
Issued Date
2006-06-01
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ISSN
00320943
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2-s2.0-33745726233
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.72, No.7 (2006), 611-614
Suggested Citation
Chikara Ichino, Hiroaki Kiyohara, Noppamas Soonthornchareonnon, Wongsatit Chuakul, Aki Ishiyama, Hitomi Sekiguchi, Miyuki Namatame, Kazuhiko Otoguro, Satoshi Omura, Haruki Yamada Antimalarial activity of biflavonoids from Ochna integerrima. Planta Medica. Vol.72, No.7 (2006), 611-614. doi:10.1055/s-2006-931569 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22892
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Title
Antimalarial activity of biflavonoids from Ochna integerrima
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Abstract
During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 (= compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1. © Georg Thieme Verlag KG Stuttgart.
