Publication: Accuracy of accessbio immunoglobulin M and total antibody rapid immunochromatographic assays for the diagnosis of acute scrub typhus infection
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Issued Date
2010-02-01
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1556679X
15566811
15566811
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2-s2.0-75749146669
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.17, No.2 (2010), 263-266
Suggested Citation
Stuart D. Blacksell, Kemajittra Jenjaroen, Rattanaphone Phetsouvanh, Vanaporn Wuthiekanun, Nicholas P.J. Day, Paul N. Newton, Wei Mei Ching Accuracy of accessbio immunoglobulin M and total antibody rapid immunochromatographic assays for the diagnosis of acute scrub typhus infection. Clinical and Vaccine Immunology. Vol.17, No.2 (2010), 263-266. doi:10.1128/CVI.00448-08 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28796
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Title
Accuracy of accessbio immunoglobulin M and total antibody rapid immunochromatographic assays for the diagnosis of acute scrub typhus infection
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Abstract
Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of IgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%). Copyright © 2010, American Society for Microbiology. All Rights Reserved.