Publication: Association of MTHFR C677T polymorphism with bone mineral density of osteoporosis in postmenopausal Thai women
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Issued Date
2013-02-01
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01252208
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2-s2.0-84873908542
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.96, No.2 (2013), 133-139
Suggested Citation
Chutaporn Tongboonchoo, Anchalee Tungtrongchitr, Benjaluck Phonrat, Sangchai Preutthipan, Rungsunn Tungtrongchitr Association of MTHFR C677T polymorphism with bone mineral density of osteoporosis in postmenopausal Thai women. Journal of the Medical Association of Thailand. Vol.96, No.2 (2013), 133-139. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32546
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Title
Association of MTHFR C677T polymorphism with bone mineral density of osteoporosis in postmenopausal Thai women
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Abstract
Background: Osteoporosis and osteopenia is rising with the increase in numbers of postmenopausal women. Methylenetetrahydrofolate reductase (MTHFR), a homocysteine catabolizing enzyme, is involved in the regulation of bone mineral density (BMD). The association between MTHFR C677T polymorphism with osteoporosis in postmenopausal Thai women is hitherto unclear. Objective: To investigate the association between MTHFR C677T and BMD in postmenopausal Thai women. Material and Method: The study subjects consisted of 346 postmenopausal Thai women volunteers. Standard dual-energy X-ray absorptiometry (DXA) was used for measurement of BMD T-score. Restriction fragment length polymorphism (RFLP) analysis was used for measurement of MTHFR C677T polymorphism. Results: In the evaluation of 346 postmenopausal Thai women heterozygous (CT) genotype had a risk of osteopenia than normal control (odds ratio (OR) = 5.66, p<0.001).BMD T-scores at each bone position revealed that heterozygous (CT) genotype had increased risk of osteopenic bones than normal controls at lumbar spines 1, 2, and 4 (OR = 2.48, p<0.001, OR = 1.98, p = 0.008 and OR = 1.83, p = 0.016 respectively), ward's triangle (OR = 2.08, p = 0.008), and head of radius (OR = 2.95, p = 0.008). Conclusion: These results indicate the possibility of using MTHFR C677T polymorphism to identify postmenopausal Thai women at high risk of osteopenia.