Publication: Potential herd protection against plasmodium falciparum infections conferred by mass antimalarial drug administrations
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Issued Date
2019-04-01
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ISSN
2050084X
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2-s2.0-85064931674
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Mahidol University
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SCOPUS
Bibliographic Citation
eLife. Vol.8, (2019)
Suggested Citation
Daniel M. Parker, Sai Thein Than Tun, Lisa J. White, Ladda Kajeechiwa, May Myo Thwin, Jordi Landier, Victor Chaumeau, Vincent Corbel, Arjen M. Dondorp, Lorenz Von Seidlein, Nicholas J. White, Richard J. Maude, François Nosten Potential herd protection against plasmodium falciparum infections conferred by mass antimalarial drug administrations. eLife. Vol.8, (2019). doi:10.7554/eLife.41023 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50218
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Title
Potential herd protection against plasmodium falciparum infections conferred by mass antimalarial drug administrations
Abstract
© Parker et al. The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success depending on adequate population participation. Here, we present a detailed spatial and temporal analysis of malaria episodes and asymptomatic infections in four villages undergoing MDA in Myanmar. In this study, individuals from neighborhoods with low MDA adherence had 2.85 times the odds of having a malaria episode post-MDA in comparison to those from high adherence neighborhoods, regardless of individual participation, suggesting a herd effect. High mosquito biting rates, living in a house with someone else with malaria, or having an asymptomatic malaria infection were also predictors of clinical episodes. Spatial clustering of non-adherence to MDA, even in villages with high overall participation, may frustrate elimination efforts.