Publication: Serotype coverage of pneumococcal conjugate vaccine and drug susceptibility of Streptococcus pneumoniae isolated from invasive or non-invasive diseases in central Thailand, 2006-2009
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Issued Date
2010-04-26
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ISSN
0264410X
Other identifier(s)
2-s2.0-77950515964
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Mahidol University
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SCOPUS
Bibliographic Citation
Vaccine. Vol.28, No.19 (2010), 3440-3444
Suggested Citation
Somporn Srifeungfung, Chanwit Tribuddharat, Sopita Comerungsee, Tanittha Chatsuwan, Vipa Treerauthanaweeraphong, Pimpha Rungnobhakhun, Pongpun Nunthapisud, Kulkanya Chokephaibulkit Serotype coverage of pneumococcal conjugate vaccine and drug susceptibility of Streptococcus pneumoniae isolated from invasive or non-invasive diseases in central Thailand, 2006-2009. Vaccine. Vol.28, No.19 (2010), 3440-3444. doi:10.1016/j.vaccine.2010.02.071 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28731
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Title
Serotype coverage of pneumococcal conjugate vaccine and drug susceptibility of Streptococcus pneumoniae isolated from invasive or non-invasive diseases in central Thailand, 2006-2009
Abstract
The serotype of 172 S. pneumoniae isolates obtained from normally sterile sites from January 2006 to February 2009 in Thai patients was evaluated. The most common serotypes were 6B, 23F, 14, 19F, and 19A in patients <5 year-old, and 6B, 19A, 23F, 4, 9V in patients >65-year old. Seven-valent pneumococcal conjugated vaccine (PCV-7) covered 70.3%, 43.6%, and 43.5% of patients <5, 5-64 and ≥65 years of age, respectively, while PCV-13 covered 81.2%, 59.7%, and 60.9%, respectively. PCV-9, PCV-10, PCV-11 had very similar coverage as PCV-7. The antibiotic susceptibility rates of the isolates from sterile sites were 88.7-95.7% for penicillin, 90.6-98.4% for cefotaxime, 92.2-100% for ofloxacin and 100% for ciprofloxacin. PCV-7 covered 83% and 100%, respectively, of penicillin and cefotaxime non-susceptible isolates in patients <5-year old. © 2010 Elsevier Ltd. All rights reserved.