Publication: Activity of vitamin D receptor agonists against dengue virus
Issued Date
2020-12-01
Resource Type
ISSN
20452322
Other identifier(s)
2-s2.0-85087288951
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports. Vol.10, No.1 (2020)
Suggested Citation
Janejira Jaratsittisin, Bin Xu, Wannapa Sornjai, Zhibing Weng, Atichat Kuadkitkan, Feng Li, Guo Chun Zhou, Duncan R. Smith Activity of vitamin D receptor agonists against dengue virus. Scientific Reports. Vol.10, No.1 (2020). doi:10.1038/s41598-020-67783-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58391
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Activity of vitamin D receptor agonists against dengue virus
Other Contributor(s)
Abstract
© 2020, The Author(s). Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to bacterial and viral pathogens. In this study a number of fused bicyclic derivatives of 1H-pyrrolo[1,2]imidazol-1-one with vitamin D receptor (VDR) agonist activity were evaluated for possible anti-DENV activity. The results showed that five of the compounds were able to significantly inhibit DENV infection. The most effective compound, ZD-3, had an EC50 value of 7.47 μM and a selective index of 52.75. The compounds were only effective when used as a post-infection treatment and treatment significantly reduced levels of infection, virus output, DENV protein expression and genome copy number. These results suggest that these VDR agonists have the potential for future development as effective anti-DENV agents.