Publication: Prognostic value of cytokine concentrations (tumor necrosis factor-α, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis
Issued Date
2000-03-15
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0034048834
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.181, No.2 (2000), 621-625
Suggested Citation
Andrew J.H. Simpson, Michael D. Smith, Gerrit Jan Weverling, Yupin Suputtamongkol, Brian J. Angus, Wipada Chaowagul, Nicholas J. White, Sander J.H. Van Deventer, Jan M. Prins Prognostic value of cytokine concentrations (tumor necrosis factor-α, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. Journal of Infectious Diseases. Vol.181, No.2 (2000), 621-625. doi:10.1086/315271 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26262
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Prognostic value of cytokine concentrations (tumor necrosis factor-α, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis
Abstract
Raised serum concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, or IL-10 are associated with mortality in patients with sepsis, but it is not known whether elevated cytokine levels are independently predictive of mortality. Cytokine assays (TNF-α, IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis. Mortality was 31.4%. APACHE II score; septicemia; plasma lactate; TNF-α, IL-6, and IL-10 concentrations; and IL- 10/TNF-α and IL-6/IL-10 ratios were each associated with outcome (P ≤ .001 for all variables). Only the APACHE II score and either IL-6 or IL-10 concentration were independent predictors of mortality, as determined by use of multiple logistic regression (with cytokine concentrations and ratios entered separately). In a multivariate analysis, including both IL-6 and IL- 10, the IL-10 concentration was no longer predictive. Therefore, APACHE II scores and either IL-6 or IL-10 concentration may be the most reliable parameters for stratification of patients in future studies of severe gram- negative sepsis.