Publication: Functional variability of Rev response element in HIV-1 primary isolates
Issued Date
2005-01-01
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ISSN
09208569
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2-s2.0-14944355081
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Mahidol University
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SCOPUS
Bibliographic Citation
Virus Genes. Vol.30, No.1 (2005), 23-29
Suggested Citation
Angsana Phuphuakrat, Prasert Auewarakul Functional variability of Rev response element in HIV-1 primary isolates. Virus Genes. Vol.30, No.1 (2005), 23-29. doi:10.1007/s11262-004-4578-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16389
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Title
Functional variability of Rev response element in HIV-1 primary isolates
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Abstract
We have previously studied sequence heterogeneity of HIV-1 Rev response element (RRE), and showed uneven variations in different stem-loops of both primary sequence and secondary structure. Here we studied the functional variation of RRE clones from a set of 10 primary isolates, and demonstrated a variation in the function of these RRE clones on the expression of Gag proteins from a truncated HIV-1 genome. The difference in Gag level was, in part, if not exclusively, resulted from the differential efficiency of RNA transport and enhancing of translation. These data suggested that variation of HIV-1 RRE may play a role in regulation of viral replication rate in HIV-1 primary isolates. © 2005 Springer Science+Business Media, Inc.
