Publication: Expression of basement membrane components in odontogenic tumors
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Issued Date
2007-11-01
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ISSN
10792104
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2-s2.0-35349001607
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Mahidol University
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SCOPUS
Bibliographic Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Vol.104, No.5 (2007), 666-675
Suggested Citation
Sopee Poomsawat, Jirapa Punyasingh, Paisarn Vejchapipat Expression of basement membrane components in odontogenic tumors. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Vol.104, No.5 (2007), 666-675. doi:10.1016/j.tripleo.2006.08.025 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24408
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Title
Expression of basement membrane components in odontogenic tumors
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Abstract
Objective: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs). Study design: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry. Results: In normal oral mucosa, linear deposits of these proteins were found at the epithelial-mesenchymal junction, but not in epithelial cytoplasm. In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types. For CCOTs, laminin 5 was found faintly in suprabasal cells, but expressed strongly in ghost cells. For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization. Conclusions: Laminin 1 may be a marker for odontogenic epithelium. Additionally, laminin 5 may be involved in ghost cell formation and initiation of calcification. © 2007 Mosby, Inc. All rights reserved.