Publication: Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand
Issued Date
2002-12-01
Resource Type
ISSN
00034983
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2-s2.0-0036973339
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Tropical Medicine and Parasitology. Vol.96, No.8 (2002), 797-802
Suggested Citation
W. Gatei, Y. Suputtamongkol, D. Waywa, R. W. Ashford, J. W. Bailey, J. Greensill, N. J. Beeching, C. A. Hart Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand. Annals of Tropical Medicine and Parasitology. Vol.96, No.8 (2002), 797-802. doi:10.1179/000349802125002202 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20184
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Title
Zoonotic species of Cryptosporidium are as prevalent as the anthroponotic in HIV-infected patients in Thailand
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Abstract
The epidemiology of chronic diarrhoea in adults with late-stage HIV infection was investigated in a prospective study in Bangkok, Thailand. During this investigation, 34 Cryptosporidium isolates were obtained from the faeces of 36 patients, with mean CD4+ counts of only 14 × 106 CD4+ cells/litre (range = 2 × 106 - 53 × 106/litre), who had symptomatic cryptosporidiosis. Genotyping of these isolates, by RFLP analysis and DNA sequencing of the hypervariable region of the 18S rRNA gene, indicated that only 17 (50%) were of the C. parvum human genotype. The rest were of C. meleagridis (seven), the C. parvum 'bovine' genotype (five), C. felis (three) and C. canis (two). Extensive genotypic heterogeneity was observed among the C. parvum isolates, and two other isolates, one of C. meleagridis and the other of C. felis, produced atypical restriction patterns and were only identified by sequencing. This appears to represent the first report of C. canis and the 'bovine' genotype of C. parvum in HIV-infected Thai patients.