Publication: Vitamin D binding protein gene polymorphism as a risk factor for Vitamin D deficiency in thais
Issued Date
2015-03-01
Resource Type
ISSN
19342403
1530891X
1530891X
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2-s2.0-84982845352
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Mahidol University
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SCOPUS
Bibliographic Citation
Endocrine Practice. Vol.21, No.3 (2015), 221-225
Suggested Citation
Pranee Thongthai, La Or Chailurkit, Suwannee Chanprasertyothin, Hataikarn Nimitphong, Piyamitr Sritara, Wichai Aekplakorn, Boonsong Ongphiphadhanakul Vitamin D binding protein gene polymorphism as a risk factor for Vitamin D deficiency in thais. Endocrine Practice. Vol.21, No.3 (2015), 221-225. doi:10.4158/EP14266.OR Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35491
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Title
Vitamin D binding protein gene polymorphism as a risk factor for Vitamin D deficiency in thais
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Abstract
© 2015 AACE. Objective: Vitamin D deficiency is related to increased risks for a number of diseases. To date, at least 3 candidate genes, vitamin D binding protein (VDBP) gene (GC), 25-hydroxylase (CYP2R1), and 7-dehydrocholesterol reductase/NAD synthetase 1 (DHCR7/NADSYN1), have been associated with serum 25-hydroxyvitamin D (25[OH]D) levels, but their influences on the prevalence of vitamin D deficiency in relation to other known risk factors have not been clearly defined.Methods: The study assessed 4,476 individuals aged 14 to 93 years from the Thailand 4th National Health Examination Survey (2008-2009) and the Electricity Generating Authority of Thailand (EGAT) (2008) cohorts. The GC rs2282679 polymorphism on chromosome 4q12-q13 was genotyped by real-time polymerase chain reaction (PCR). Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Vitamin D deficiency was defined as a 25(OH)D concentration <20 ng/mL.Results: Data were expressed as mean ± SD. There were 2,747 (61.4%) males and 1,729 (38.6%) females in the study, with an average body mass index (BMI) of 23.7 ± 4.2 kg/m2 and a mean total 25(OH)D of 28.9 ± 9.0 ng/mL. Serum 25(OH)D levels decreased progressively with the presence of the C allele. Using multiple logistic regression analysis, vitamin D deficiency was significantly associated with the GC rs2282679 genotype (odds ratio [OR] per C allele 1.80, 95% confidence interval CI 1.57-2.01), independent of established risk factors for vitamin D deficiency including age, sex, and BMI.Conclusion: A specific GC gene polymorphism is associated with lower 25(OH)D levels independent of age, sex, and adiposity in Thai subjects.