Publication: Clinical Characteristics of Late-Onset Cytomegalovirus Infection After Kidney Transplantation
Issued Date
2021-09-01
Resource Type
ISSN
18732623
00411345
00411345
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2-s2.0-85112574852
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Mahidol University
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SCOPUS
Bibliographic Citation
Transplantation Proceedings. Vol.53, No.7 (2021), 2267-2271
Suggested Citation
Sirapob Nuansri, Surasak Kantachuvesiri, Siriorn P. Watcharananan, Charat Thongprayoon, Wisit Cheungpasitporn, Jackrapong Bruminhent Clinical Characteristics of Late-Onset Cytomegalovirus Infection After Kidney Transplantation. Transplantation Proceedings. Vol.53, No.7 (2021), 2267-2271. doi:10.1016/j.transproceed.2021.07.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77906
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Title
Clinical Characteristics of Late-Onset Cytomegalovirus Infection After Kidney Transplantation
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Abstract
Background: Late-onset cytomegalovirus (CMV) infection (LCI) has been emerging mong solid-organ transplant recipients. We explored clinical characteristics, risk factors, and outcomes of LCI in kidney transplantation (KT) recipients. Methods: A retrospective study of all adult KT recipients with LCIs (that occurred >6 months after transplant) from 2016 to 2018 was conducted. Clinical characteristics and outcomes were extracted. Risk factors of LCI were analyzed using Cox proportional hazards models. Results: A total of 518 KT recipients were included. Ninety-eight percent had donor CMV-seropositive and recipient CMV-seropositive status (D+/R+). Ten (2%) KT recipients developed LCI with a median onset of 14 (interquartile range, 8-15) months. Those included asymptomatic CMV infection (40%) and tissue-invasive disease (60%). CMV D+/R– serostatus and a prior episode of rejection within 6 months were associated with LCI (hazard ratio, 17.35; 95% confidence interval, 3.60-83.63; P < .001) and (hazard ratio, 38.15; 95% confidence interval, 6.15-236.72; P < .001), respectively. There was no difference in the rate of allograft failure and mortality in those with LCI compared with those with early-onset CMV infection. Conclusion: LCI is uncommon after KT. Those with CMV seromismatch and a prior episode of rejection were more likely to develop LCI. Clinical and allograft outcomes were not different among each group.