Publication: Proinflammatory cytokines and chemokines in humans with Japanese encephalitis
Issued Date
2004-11-01
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ISSN
00221899
DOI
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2-s2.0-6944246228
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.190, No.9 (2004), 1618-1626
Suggested Citation
Peter M. Winter, Minh Dung Nguyen, Thi Loan Ha, Rachel Kneen, Bridget Wills, Thi Thu Le, Deborah House, Nicholas J. White, Jeremy J. Farrar, C. Anthony Hart, Tom Solomon Proinflammatory cytokines and chemokines in humans with Japanese encephalitis. Journal of Infectious Diseases. Vol.190, No.9 (2004), 1618-1626. doi:10.1086/423328 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21506
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Title
Proinflammatory cytokines and chemokines in humans with Japanese encephalitis
Abstract
Background. Japanese encephalitis virus (JEV), the mosquito-borne flavivirus, annually causes an estimated 35,000-50,000 encephalitis cases and 10,000-15,000 deaths in Asia, and there is no antiviral treatment. The role played by the immune response in determining the outcome of human infection with JEV is poorly understood, although, in animal models of flavivirus encephalitis, unregulated proinflammatory cytokine responses can be detrimental. Methods. We studied the innate, cellular, and humoral immune responses in 118 patients infected with JEV, of whom 13 (11%) died. Results. Levels of interferon (IFN)-α, the proinflammatory cytokine interleukin (IL)-6, and the chemokine IL-8 were all higher in the cerebrospinal fluid (CSF) of the nonsurvivors than of the survivors (P = .04, P = .006, and P = .04, respectively), as were both the IL-6:IL-4 ratio in CSF (a marker of the balance of pro- and anti-inflammatory cytokines) and the level of the chemokine RANTES (regulated on activation, normally T cell expressed and secreted) in plasma (P = .03). In contrast, levels of immunoglobulin (Ig) M and IgG in CSF and of IgM in plasma were higher in the survivors (P = .035, P = .003, and P = .009, respectively). Levels of IFN-γ and nitric oxide did not vary with outcome. Conclusions. During JEV infection, elevated levels of proinflammatory cytokines and chemokines are associated with a poor outcome, but whether they are simply a correlate of severe disease or contribute to pathogenesis remains to be determined.