Publication:
Nevirapine levels after discontinuation of rifampicin therapy and 60-week efficacy of nevirapine-based antiretroviral therapy in HIV-infected patients with tuberculosis

Issued Date

2007-01-01

Resource Type

Article

ISSN

10584838

DOI

10.1086/510078

Other identifier(s)

2-s2.0-33845720528

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Clinical Infectious Diseases. Vol.44, No.1 (2007), 141-144

Suggested Citation

Weerawat Manosuthi, Kiat Ruxrungtham, Sirirat Likanonsakul, Wisit Prasithsirikul, Yaowarat Inthong, Thanongsri Phoorisri, Somnuek Sungkanuparph Nevirapine levels after discontinuation of rifampicin therapy and 60-week efficacy of nevirapine-based antiretroviral therapy in HIV-infected patients with tuberculosis. Clinical Infectious Diseases. Vol.44, No.1 (2007), 141-144. doi:10.1086/510078 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25080

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Title

Nevirapine levels after discontinuation of rifampicin therapy and 60-week efficacy of nevirapine-based antiretroviral therapy in HIV-infected patients with tuberculosis

Author(s)

Weerawat Manosuthi
 Kiat Ruxrungtham
 Sirirat Likanonsakul
 Wisit Prasithsirikul
 Yaowarat Inthong
 Thanongsri Phoorisri
 Somnuek Sungkanuparph

Other Contributor(s)

Thailand Ministry of Public Health
 Chulalongkorn University
 Mahidol University
 Bamrasnaradura Infectious Disease Institute

Abstract

Seventy patients with human immunodeficiency virus (HIV) and tuberculosis coinfection who initiated nevirapine-based antiretroviral therapy and had trough nevirapine levels determined while receiving rifampicin were enrolled in a study. After discontinuation of rifampicin therapy, mean nevirapine levels (± standard deviation) increased from 5.4 ± 3.5 mg/L to 6.4 ± 3.4 mg/L (P = .047), but no nevirapine-related adverse events occurred. There was no statistically significant difference in 60-week antiviral efficacy between these patients and patients receiving nevirapine-based antiretroviral therapy alone (P > .05). © 2006 by the Infectious Diseases Society of America. All rights reserved.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/25080

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Scopus 2006-2010