Publication: In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels
Issued Date
2004-01-28
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ISSN
03785173
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2-s2.0-0346729794
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.269, No.2 (2004), 303-310
Suggested Citation
Assadang Polnok, J. Coos Verhoef, Gerrit Borchard, Narong Sarisuta, Hans E. Junginger In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels. International Journal of Pharmaceutics. Vol.269, No.2 (2004), 303-310. doi:10.1016/j.ijpharm.2003.09.022 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21809
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Title
In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels
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Abstract
The aim of this study was to investigate and modify the potential of drug-delivery systems based on superporous hydrogel (SPH) for improving the intestinal transport of the peptide drug desmopressin in vitro. The swelling properties and mechanical strength of SPHs were studied. The release profile of desmopressin was investigated by changing the composition of excipients in the formulations. Subsequently, the ability of the SPH-based drug-delivery systems to enhance the transport of desmopressin across porcine intestine was performed in vitro. The swelling properties and mechanical strength of SPHs were affected by the addition of the disintregrant AcDiSol®. This disintregrant reduced the swelling ratio to 10% and the time to 80% swelling was retarded by 3-5min in comparison to the negative control. AcDiSol® increased the mechanical strength, according to the increasing of penetration pressure value, the pressure that the punch can penetrate the gel, of the SPHs. The transport of desmopressin across the intestinal mucosa in vitro was enhanced four- and six-fold by applying SPH, with AcDiSol®, in the absence and presence of the additional absorption enhancer trimethyl chitosan chloride, respectively, in comparison to the negative control. It is concluded that drug-delivery systems based on SPHs are promising for enhancing the intestinal absorption of desmopressin. © 2003 Elsevier B.V. All rights reserved.