Publication: Expression of Aquaporin-1, -2 and -4 in Mice with a Spontaneous Mutation Leading to Hydronephrosis
Accepted Date
August 2011
Issued Date
2012
Resource Type
Language
eng
Rights Holder(s)
Elsevier (available from Sciencedirect)
Bibliographic Citation
Journal of Comparative Pathology. Vol.146, No. 4 (2012), 332–337
Suggested Citation
S. Ampawong, A. Klincomhum, W. Likitsuntonwong, O. Singha, T. Ketjareon, Y. Panavechkijkul, K.-M. Zaw, K. Kengkoom Expression of Aquaporin-1, -2 and -4 in Mice with a Spontaneous Mutation Leading to Hydronephrosis. Journal of Comparative Pathology. Vol.146, No. 4 (2012), 332–337. doi:10.1016/j.jcpa.2011.08.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22817
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Title
Expression of Aquaporin-1, -2 and -4 in Mice with a Spontaneous Mutation Leading to Hydronephrosis
Abstract
This study investigates the expression of aquaporin-1, -2 and -4 in mice with a spontaneously-arising mutation that leads to hydronephrosis (ICR/Mlac-hydro mice). The mutant mice developed bilateral non-obstructive hydronephrosis without evidence of interstitial fibrosis or glomerulosclerosis. The mice had no abnormality in blood urea nitrogen or creatinine concentrations or in urine specific gravity. Despite the severity of the renal damage the mice grew and reproduced normally. Kidneys from the mutant mice had reduced expression of all three aquaporins compared with wild type mice. The reduction in aquaporin was proportional to the degree of hydronephrosis, but this change did not appear to be associated with disturbance of urinary function.