Publication: Significant association between vitamin D deficiency and sepsis: A systematic review and meta-analysis
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2015-06-04
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14712253
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2-s2.0-84930649625
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Mahidol University
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SCOPUS
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BMC Anesthesiology. Vol.15, No.1 (2015)
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Sikarin Upala, Anawin Sanguankeo, Nitipong Permpalung Significant association between vitamin D deficiency and sepsis: A systematic review and meta-analysis. BMC Anesthesiology. Vol.15, No.1 (2015). doi:10.1186/s12871-015-0063-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36409
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Significant association between vitamin D deficiency and sepsis: A systematic review and meta-analysis
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© 2015 Upala et al.; licensee BioMed Central. Background: A number of observational studies have found an association between low vitamin D levels and risk of sepsis. We conducted a systematic review and meta-analysis to determine the overall estimate of risk. Methods: This was a systematic review and meta-analysis conducted by online searches (CENTRAL, PubMed/MEDLINE, and EMBASE) was registered in PROSPERO (CRD42014014767). Primary outcome was incidence, prevalence, relative risk or odds ratio of having sepsis or bloodstream infection between patients with vitamin D deficiency and controls. Results: The initial search yielded 647 articles. Twenty-one articles underwent full-length review and data were extracted from 10 observational studies. Pooled odds ratio of sepsis in participants with vitamin D deficiency was 1.78 (95 % confidence interval [CI] = 1.55 to 2.03, p < 0.01) compared with controls in studies that reported participant numbers and was 1.45 (95 % CI = 1.26 to 1.66, p < 0.01) in studies that reported an adjusted odds ratio of vitamin D deficiency for developing sepsis. Statistical between-study heterogeneity was low (I2= 0 % and 5 %, respectively). Standardized mean difference of 25-hydroxyvitamin D levels in patients with sepsis and controls was -0.24 (95 % CI = -0.49 to 0.00, p = 0.05) and lower in the sepsis group compared with non-sepsis or control participants. The statistical between-study heterogeneity (I2) was 0 %. Conclusion: Vitamin D deficiency were associated with an increased susceptibility of sepsis.