Publication: Genetic similarity of HIV type 1 subtype E in a recent outbreak among injecting drug users in northern Vietnam to strains in Guangxi Province of southern China
2
Issued Date
1999-09-01
Resource Type
ISSN
08892229
Other identifier(s)
2-s2.0-0033200064
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
AIDS Research and Human Retroviruses. Vol.15, No.13 (1999), 1157-1168
Suggested Citation
Kayoko Kato, Teiichiro Shiino, Shigeru Kusagawa, Hironori Sato, Kyoko Nohtomi, Kayo Shibamura, Nguyen Tran Hien, Pham Kim Chi, Truong Xuan Lien, Mai Hoang Anh, Hoang Thuy Long, Gaysorn Bunyaraksyotin, Yoshiko Fukushima, Mitsuo Honda, Chantapong Wasi, Shudo Yamazaki, Yoshiyuki Nagai, Yutaka Takebe Genetic similarity of HIV type 1 subtype E in a recent outbreak among injecting drug users in northern Vietnam to strains in Guangxi Province of southern China. AIDS Research and Human Retroviruses. Vol.15, No.13 (1999), 1157-1168. doi:10.1089/088922299310250 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25431
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Genetic similarity of HIV type 1 subtype E in a recent outbreak among injecting drug users in northern Vietnam to strains in Guangxi Province of southern China
Abstract
To investigate the molecular epidemiology of a recent HIV-1 outbreak in northern Vietnam and its relation to the epidemic in surrounding areas, we analyzed 17 HIV-positive blood specimens from 3 heterosexuals, 2 sexually transmitted disease patients, and 12 injecting drug users (IDUs), collected in 4 provinces near Hanoi in 1998. These were compared with the specimens from Ho Chi Minh City (n = 10) and An Giang Province (n = 10) in southern Vietnam and with published sequences from neighboring countries. Genetic subtyping based on the env C2/V3 sequences revealed that HIV-1 subtype E predominated throughout Vietnam in all risk populations; the exception was one typical United States-European-type HIV-1 subtype B detected in a patient in He Chi Minh City, the first case of HIV infection identified in Vietnam in 1990. The HIV-1 subtype E sequences identified in 9 of the 12 IDUs from northern provinces were closely related phylogenetically to those in IDUs in nearby Guangxi Province of China, and also shared a common amine acid signature downstream of the env V3 loop region. The low interperson nucleotide diversity among IDUs in northern Vietnam supports the view that HIV-1 subtype E was introduced recently among IDUs in northern Vietnam. These data indicate a linkage between HIV-1 circulating among IDUs in northern Vietnam and southern China, and suggest recent transborder introductions as the likely source of HIV-1 subtype E in northern Vietnam.