Publication: An omics perspective on molecular biomarkers for diagnosis, prognosis, and therapeutics of cholangiocarcinoma
Issued Date
2015-01-01
Resource Type
ISSN
23144378
2314436X
2314436X
Other identifier(s)
2-s2.0-84941670985
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Genomics. Vol.2015, (2015)
Suggested Citation
Pattaya Seeree, Phorutai Pearngam, Supeecha Kumkate, Tavan Janvilisri An omics perspective on molecular biomarkers for diagnosis, prognosis, and therapeutics of cholangiocarcinoma. International Journal of Genomics. Vol.2015, (2015). doi:10.1155/2015/179528 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35523
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
An omics perspective on molecular biomarkers for diagnosis, prognosis, and therapeutics of cholangiocarcinoma
Other Contributor(s)
Abstract
© 2015 Pattaya Seeree et al. Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy arising from the epithelial bile duct. The lack of early diagnostic biomarkers as well as therapeutic measures results in severe outcomes and poor prognosis. Thus, effective early diagnostic, prognostic, and therapeutic biomarkers are required to improve the prognosis and prolong survival rates in CCA patients. Recent advancement in omics technologies combined with the integrative experimental and clinical validations has provided an insight into the underlying mechanism of CCA initiation and progression as well as clues towards novel biomarkers. This work highlights the discovery and validation of molecular markers in CCA identified through omics approaches. The possible roles of these molecules in various cellular pathways, which render CCA carcinogenesis and progression, will also be discussed. This paper can serve as a reference point for further investigations to yield deeper understanding in the complex feature of this disease, potentially leading to better approaches for diagnosis, prognosis, and therapeutics.