Publication: Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes
Issued Date
1992-01-01
Resource Type
ISSN
01688227
Other identifier(s)
2-s2.0-0026722372
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Diabetes Research and Clinical Practice. Vol.18, No.1 (1992), 17-21
Suggested Citation
Napatawn Tandhanand-Banchuin, Wannapa Kespichayawatana, Sathit Vannasaeng, Chatri Banchuin, Tawee Laohapand, Sukij Panpimarnmas, Kovit Pattanapanyasat, Suttipant Sarasombath, H. Kyle Webster Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. Diabetes Research and Clinical Practice. Vol.18, No.1 (1992), 17-21. doi:10.1016/0168-8227(92)90050-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22277
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Title
Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes
Abstract
A case of fibrocalculous pancreatic diabetes (FCPD) is reported for which antibody and cellular immune characteristics were determined. The patient, a Thai woman, had serum islet cell antibodies (ICA) that were detected by both immunoperoxidase staining and an indirect enzyme-linked immunosorbent assay (ELISA). Serum anti-human insulin antibodies were negative by a displacement ELISA. Lymphoproliferation assay against pancreatic antigen prepared from a blood group O cadaveric donor was positive. Increased CD8+lymphocytes were observed using direct immunofluorescence staining and flow cytometry. CD4+T lymphocytes, B lymphocytes and NK cells were within normal levels. These findings provide evidence for autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. © 1992.