Publication: Reticulocyte analysis in iron deficiency anemia and hemolytic anemia
2
Issued Date
2000-12-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0034154015
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.83, No.SUPPL. 1 (2000)
Suggested Citation
Punnee Butthep Reticulocyte analysis in iron deficiency anemia and hemolytic anemia. Journal of the Medical Association of Thailand. Vol.83, No.SUPPL. 1 (2000). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26073
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Reticulocyte analysis in iron deficiency anemia and hemolytic anemia
Author(s)
Other Contributor(s)
Abstract
Reticulocyte analysis was studied in 28 anemic patients, 15 with iron deficiency anemia (IDA), and 13 with hemolytic anemia including 9 glucose 6 phosphate dehydrogenase deficiency (G6PD def.), and 4 with G6PD def. combined with HbE trait or a thalassemia trait (α thal trait). The reticulocyte analysis among these patients showed the increased number of reticulocyte percentage with low degree of maturation in both IDA and G6PD def. patients. The significantly decreased reticulocyte hemoglobin content (CHr) was found in IDA (CHr= 21.74 ± 4.61 pg in IDA vs 28.41 ± 1.34 pg in normal; p-value = < 0.0001), whereas, increased CHr was found in G6PD def. patients. In addition, the G6PD def. patients also showed a significant increase in mean corpuscular reticulocyte volume (MCVr) when compared to normal (MCVr = 132.0 ± 8.39 fl. in G6PD def. vs 110.39 ± 5.09 in normal; p - value = < 0.0001). However, a significant decrease in MCVr was found in IDA patients (MCVr = 95.89 ± 8.57 fl.; p-value = < 0.0001 vs normal). From this study, we can suggest that the reticulocyte hemoglobin content (CHr) and mean corpuscular reticulocyte volume (MCVr) are the important defects in patients with iron deficiency anemia.