Publication: Second trimester pregnancy termination: A comparison of 600 and 800 micrograms of intravaginal misoprostol
Issued Date
2001-01-01
Resource Type
ISSN
13418076
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2-s2.0-0034898538
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Obstetrics and Gynaecology Research. Vol.27, No.3 (2001), 125-128
Suggested Citation
Yongyoth Herabutya, Boonsri Chanrachakul, Piyaporn Punyavachira Second trimester pregnancy termination: A comparison of 600 and 800 micrograms of intravaginal misoprostol. Journal of Obstetrics and Gynaecology Research. Vol.27, No.3 (2001), 125-128. doi:10.1111/j.1447-0756.2001.tb01235.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26866
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Title
Second trimester pregnancy termination: A comparison of 600 and 800 micrograms of intravaginal misoprostol
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Abstract
Objective: To compare the effectiveness of 600 and 800 μg of misoprostol administered intravaginally every 12 hours for termination of second trimester pregnancies. Methods: One hundred and forty-three pregnant women at 14-26 weeks' gestation were randomized in 2 groups to receive either 600 μg (N = 67), or 800 μg (N = 76) of intravaginal misoprostol every 12 hours until abortion was induced. Results: The incidences of abortion within 24 hours after initial drug administration were 82.1% (n = 55) and 78.9% (n = 60), within 48 hours 92.5% (n = 62) and 92.1% (n = 70), the mean abortion intervals were 15.2 (10.5, 20.8) hours and 15.3 (10.2, 21.8) hours, the complete abortion rates 77.6% (n = 52) and 72.4% (n = 55), and body temperature of more than 38°C were 26.9% (n = 18) and 71.1% (n = 54, p = < 0.001) in the 600 and 800 μg group, respectively. All other side-effects were similar between the 2 groups. Conclusion: In consideration of effectiveness and febrile complication, we suggest that 600 μg applied every 12 hours is the most appropriate dose to use for second trimester termination.