Publication: Rotavirus within day care centres in Oxfordshire, UK: Characterization of partial immunity
Issued Date
2008-12-06
Resource Type
ISSN
17425662
17425689
17425689
Other identifier(s)
2-s2.0-58749090951
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Royal Society Interface. Vol.5, No.29 (2008), 1481-1490
Suggested Citation
L. J. White, J. Buttery, B. Cooper, D. J. Nokes, G. F. Medley Rotavirus within day care centres in Oxfordshire, UK: Characterization of partial immunity. Journal of the Royal Society Interface. Vol.5, No.29 (2008), 1481-1490. doi:10.1098/rsif.2008.0115 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18801
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Title
Rotavirus within day care centres in Oxfordshire, UK: Characterization of partial immunity
Author(s)
Abstract
Repeated measures data for rotavirus infection in children within 14 day care centres (DCCs) in the Oxfordshire area, UK, are used to explore aspects of rotavirus transmission and immunity. A biologically realistic model for the transmission of infection is presented as a set of probability models suitable for application to the data. Two transition events are modelled separately: incidence and recovery. The complexity of the underlying mechanistic model is reflected in the choice of the fixed variables in the probability models. Parameter estimation was carried out using a Bayesian Markov chain Monte Carlo method.We use the parameter estimates obtained to build a profile of the natural history of rotavirus reinfection in an individual child. We infer that rotavirus transmission in children in DCCs is dependent on the DCC prevalence, with symptomatic infection of longer duration, but no more infectious per day of infectious period, than asymptomatic infection. There was evidence that a recent previous infection reduces the risk of disease and, to a lesser extent, reinfection, but not duration of infection. The results provide evidence that partial immunity to rotavirus infection develops over several time scales. © 2008 The Royal Society.