Publication: HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV
Issued Date
1996-03-01
Resource Type
ISSN
00368075
Other identifier(s)
2-s2.0-0345717207
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science. Vol.271, No.5253 (1996), 1291-1293
Suggested Citation
Luis E. Soto-Ramirez, Boris Renjifo, Mary F. McLane, Richard Marlink, Cari O'Hara, Ruengpung Sutthent, Chantapong Wasi, Prakong Vithayasai, Vicharn Vithayasai, Chatchawann Apichartpiyakul, Prasert Auewarakul, Victor Peña Cruz, Dao Shan Chui, Rapin Osathanondh, Kenneth Mayer, Tun Hou Lee, Max Essex HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV. Science. Vol.271, No.5253 (1996), 1291-1293. doi:10.1126/science.271.5253.1291 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17844
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Title
HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV
Abstract
Heterosexual transmission by vaginal intercourse accounts for most transmission of human immunodeficiency virus-type 1 (HIV-1) in Africa and Asia but is less important in the HIV-1 epidemics of the United States and Western Europe. Epithelial Langerhans' cells (LCs) represent a possible source of initial cell contact for vaginal infection. Fifteen primary isolates of HIV-1 from U.S. homosexuals and 18 HIV-1 isolates from Thailand heterosexuals were evaluated for growth in LCs of U.S. origin. All the viruses from the Thai heterosexuals, which were subtype E, grew more efficiently in the LCs than any of the viruses from the U.S. homosexuals, which are subtype B. These results suggest that LC tropism is associated with the efficiency of heterosexual transmission of HIV.