Publication: Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity
Issued Date
2011-01-01
Resource Type
ISSN
18715281
Other identifier(s)
2-s2.0-81155126242
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Inflammation and Allergy - Drug Targets. Vol.10, No.6 (2011), 455-463
Suggested Citation
Thararat Nualsanit, Pleumchitt Rojanapanthu, Wandee Gritsanapan, Thiwanporn Kwankitpraniti, Kyung Won Min, Seung Joon Baek Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity. Inflammation and Allergy - Drug Targets. Vol.10, No.6 (2011), 455-463. doi:10.2174/187152811798104908 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12100
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kB activity
Abstract
Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this anti-inflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-KB (NF-kB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases. © 2011 Bentham Science Publishers.