Publication: Thrombotic complications during induction chemotherapy of acute childhood lymphoblastic leukemia
Issued Date
2002-08-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0036702891
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.85, No.SUPPL. 2 (2002)
Suggested Citation
Suthida Kankirawatana, Kleebsabai Sanpakit, Patraporn Akkabutr, Chularatana Mahasandana, Gavivann Veerakul, Voravarn S. Tanphaichitr, Lerlugsn Suwantol Thrombotic complications during induction chemotherapy of acute childhood lymphoblastic leukemia. Journal of the Medical Association of Thailand. Vol.85, No.SUPPL. 2 (2002). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20446
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Thrombotic complications during induction chemotherapy of acute childhood lymphoblastic leukemia
Other Contributor(s)
Abstract
The incidence of thrombosis during induction chemotherapy of acute childhood lymphoblastic leukemia (ALL) patients was 6 found to be in 105 (5.7%). There were 4 cerebral infarctions, 1 superior vena cava (SVC) obstruction and I deep vein thrombosis. Among these, 2 of them died. A prospective study was further conducted of the change in coagulation and anticoagulation factors during 6 weeks of induction chemotherapy. It was found that the activated partial thromboplastin time (aPTT) was within normal range in all cases throughout 6 weeks, while prothrombin time (PT) and thrombin time (TT) were slightly prolonged, especially during the first 3 weeks of this phase. The natural anticoagulant panels which included protein C (PC), protein S (PS) and antithrombin III (AT III) and also fibrinogen level, were lower during the first 3 weeks and reached its nadir during the second and third week. The lower level of natural anticoagulants might be an important predisposing factor for the occurrence of thrombosis in these patients.