Publication: Iodine/persulfate-promoted site-selective direct thiolation of quinolones and uracils
Issued Date
2019-09-27
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ISSN
14645416
00404020
00404020
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2-s2.0-85071389193
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Mahidol University
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SCOPUS
Bibliographic Citation
Tetrahedron. Vol.75, No.39 (2019)
Suggested Citation
Danupat Beukeaw, Medena Noikham, Sirilata Yotphan Iodine/persulfate-promoted site-selective direct thiolation of quinolones and uracils. Tetrahedron. Vol.75, No.39 (2019). doi:10.1016/j.tet.2019.130537 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50071
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Title
Iodine/persulfate-promoted site-selective direct thiolation of quinolones and uracils
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Abstract
© 2019 Elsevier Ltd A simple and general method for direct thiolation of 4-quinolones with disulfides or thiols under I2/K2S2O8 system has been developed. Under the optimal conditions, the C–S bond coupling can take place effectively with good to decent yields and excellent regioselectivity of the S-linked products. The established metal-free site-selective approach was also applicable to transform a range of uracil substrates to the thio-substituted products under mild conditions. Further transformation to the sulfone derivatives can be conveniently performed in one-pot. These easy-to-handle protocols represent a useful and interesting synthetic alternative with good substrate scope and functional group compatibility.