Publication: Polymorphonuclear leucocyte elastase in plasmodium falciparum malaria
Issued Date
1992-01-01
Resource Type
ISSN
18783503
00359203
00359203
Other identifier(s)
2-s2.0-0027074350
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.86, No.6 (1992), 598-601
Suggested Citation
S. Pukrittayakamee, R. Clemens, C. Pramoolsinsap, H. E. Karges, S. Vanijanonta, D. Bunnag, N. J. White Polymorphonuclear leucocyte elastase in plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.86, No.6 (1992), 598-601. doi:10.1016/0035-9203(92)90143-Z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22318
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Polymorphonuclear leucocyte elastase in plasmodium falciparum malaria
Abstract
Sixty-one patients with falciparum malaria were studied prospectively to determine the plasma concentrations of the lysosomal proteinase, polymorphonuclear leucocyte elastase (PMN-elastase) and their relationship to disease severity. The patients were divided into 3 groups; severe (parasitaemia >5%) or vital organ dysfunction (n=23), moderate (parasitaemia l%-5% without complications) (n= 15), and mild (parasitaemia <l%)(n=23). The mean plasma PMN-elastase level in 10 healthy Thai volunteers was 49�5 (SD=21�6) ng/ml (range 33-65 ng/ml). Plasma PMN-elastase concentrations on admission were elevated (>2�SD above normal) in all patients with severe malaria and were above 100 ng/ml in 86-6% and 65% of the moderately severe and mild patients respectively. PMN-elastase levels during the first 3 hospital days were significantly higher in severe malaria compared with the other 2 groups (P=<0�001-0 013). The levels decreased as the patients became afebrile and aparasitaemic. Admission plasma concentrations of PMN-elastase correlated directly with bilirubin (rs=0�50, P<0�001), serum glutamic oxalacetic transaminase (rs=0�54, P0�001), parasite count (rs=0�62, P<0�001), blood urea nitrogen (rs=0�54, P<0�001) and inversely with antithrombin III activity (rs=0�54, PcO-OOl) and the platelet count (rs=0�58, P<0�001). Polymorphonuclear leucocyte activation may contribute to the pathogenesis of severe malaria. � 1992, SPIE. © 1992, Oxford University Press. All rights reserved.
