Publication: A pilot phase II study of capecitabine plus cisplatin in the treatment of recurrent carcinoma of the uterine cervix
Issued Date
2007-11-01
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ISSN
00302414
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2-s2.0-37049012252
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Mahidol University
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SCOPUS
Bibliographic Citation
Oncology. Vol.72, No.1-2 (2007), 33-38
Suggested Citation
Mongkol Benjapibal, Chaiyod Thirapakawong, Chairatana Leelaphatanadit, Suwanit Therasakvichya, Perapong Inthasorn A pilot phase II study of capecitabine plus cisplatin in the treatment of recurrent carcinoma of the uterine cervix. Oncology. Vol.72, No.1-2 (2007), 33-38. doi:10.1159/000111086 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24091
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Title
A pilot phase II study of capecitabine plus cisplatin in the treatment of recurrent carcinoma of the uterine cervix
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Abstract
Background: To assess the efficacy and tolerability of combination therapy with capecitabine and cisplatin in patients with recurrent carcinoma of the uterine cervix. Methods: Sixteen patients were treated with oral capecitabine (1,000 mg/m2 twice daily, days 1-14) and intravenous cisplatin (50 mg/m2 on day 1 every 3 weeks) for a maximum of six cycles. Results: Their median age was 50 years (31-74 years). Ten patients (63%) had recurrent disease outside the radiation field. The overall response rate was 50% (95% confidence interval 26-75%); 4 patients had complete response (25%). The overall response rate was 33% in patients with recurrent disease within the previous irradiated field and 60% in patients with tumor outside the irradiated field. The median time to progression was 9 months, with a median overall survival of 23 months. The majority of adverse events were mild and there were no grade 4 adverse events. Hematological toxicity was the most frequent adverse event with grade 3 neutropenia in 19% of patients. Grade 2 and 3 hand-foot syndrome occurred in 38 and 6% of the patients, respectively. There were no chemotherapy-related deaths. Conclusion: The combination of capecitabine plus cisplatin is a clinically active regimen with acceptable tolerability for patients with recurrent carcinoma of the uterine cervix. Copyright © 2007 S. Karger AG.