Publication:
Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry

Issued Date

2006-07-01

Resource Type

Article

ISSN

18607187
18607179

DOI

10.1002/cmdc.200600041

Other identifier(s)

2-s2.0-33745587210

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

ChemMedChem. Vol.1, No.7 (2006), 702-705

Suggested Citation

Facundo M. Fernández, Robert B. Cody, Michael D. Green, Christina Y. Hampton, Rose McGready, Sivong Sengaloundeth, Nicholas J. White, Paul N. Newton Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry. ChemMedChem. Vol.1, No.7 (2006), 702-705. doi:10.1002/cmdc.200600041 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23019

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Title

Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry

Author(s)

Facundo M. Fernández
 Robert B. Cody
 Michael D. Green
 Christina Y. Hampton
 Rose McGready
 Sivong Sengaloundeth
 Nicholas J. White
 Paul N. Newton

Other Contributor(s)

Georgia Institute of Technology
 JEOL USA Inc.
 National Center for Infectious Diseases
 Shoklo Malaria Research Unit
 Ministry of Health
 Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration
 University of Oxford
 Mahidol University

Abstract

Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Pharmacology, Toxicology and Pharmaceutics

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/23019

Collections

Scopus 2006-2010