Publication: Fighting fire with fire: Mass antimalarial drug administrations in an era of antimalarial resistance
Issued Date
2015-01-01
Resource Type
ISSN
17448336
14787210
14787210
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2-s2.0-84929255823
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Anti-Infective Therapy. Vol.13, No.6 (2015), 715-730
Suggested Citation
Lorenz Von Seidlein, Arjen Dondorp Fighting fire with fire: Mass antimalarial drug administrations in an era of antimalarial resistance. Expert Review of Anti-Infective Therapy. Vol.13, No.6 (2015), 715-730. doi:10.1586/14787210.2015.1031744 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36147
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Title
Fighting fire with fire: Mass antimalarial drug administrations in an era of antimalarial resistance
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Abstract
© 2015 Informa UK, Ltd. The emergence and spread of antimalarial resistance has been a major liability for malaria control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic consequences for people in malaria-endemic regions, particularly in sub-Saharan Africa. The recent emergence of artemisinin-resistant P. falciparum strains is of highest concern. Current efforts to contain artemisinin resistance have yet to show success. In the absence of more promising plans, it has been suggested to eliminate falciparum malaria from foci of artemisinin resistance using a multipronged approach, including mass drug administrations. The use of mass drug administrations is controversial as it increases drug pressure. Based on current knowledge it is difficult to conceptualize how targeted malaria elimination could contribute to artemisinin resistance, provided a full treatment course is ensured.