Publication: A hospital-based study of acute viral infections of the respiratory tract in thai children, with emphasis on laboratory diagnosis
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Issued Date
1990-01-01
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ISSN
01620886
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2-s2.0-0025223028
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Mahidol University
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SCOPUS
Bibliographic Citation
Reviews of Infectious Diseases. Vol.12, (1990), S988-S994
Suggested Citation
Pilaipan Putbavatbana, Cbantapong Wasi, Uraiwan Kositanont, Subbaree Suwanjutbae, Teeracbai Cbantarojanasiri, Wannee Kantakamalakul, Pakanee Kantawateera, Prasert Tbongcbaroen A hospital-based study of acute viral infections of the respiratory tract in thai children, with emphasis on laboratory diagnosis. Reviews of Infectious Diseases. Vol.12, (1990), S988-S994. doi:10.1093/clinids/12.Supplement_8.S988 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16156
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Title
A hospital-based study of acute viral infections of the respiratory tract in thai children, with emphasis on laboratory diagnosis
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Abstract
The hospital-based study described here examined the viruses found in 738 children < 5 years old who presented at Ramathibodi Hospital, Bangkok, Thailand, from January 1986 to December 1987 with acute respiratory tract infections. Three methods for detection of viral infection are compared: direct examination of epithelial cells of the respiratory tract with the use of fluorescent antibody staining, isolation of virus, and measurement of antibody in acute- and convalescent-phase sera. Viral infections were found in 44.70/0 of the study population. Diagnosis by the examination of epithelial cells with the fluorescent antibody staining procedure was found to have several deficiencies; however, this technique was the most sensitive for diagnosis of infection due to respiratory syncytial virus. Isolation of virus was the best method for identification of adenoviruses, parainfluenza 1 and 3 viruses, and influenza B virus. Problems associated with serodiagnosis included failure to obtain specimens of convalescent-phase blood in 24.50/0 of cases and insensitivity of serodiagnosis for young children except for the identification of antibody to influenza A virus. The combination of all three tests yielded the best rate of detection of virus. © 1990 by The University of Chicago.