Research Communications in Chemical Pathology and Pharmacology. Vol.51, No.2 (1986), 265-268
Suggested Citation
T. Glinsukon, S. Sinlapanapaporn, M. Chulasamaya Inhibitory effect of cytochalasins on the motility of rat epididymal spermatozoa in vitro. Research Communications in Chemical Pathology and Pharmacology. Vol.51, No.2 (1986), 265-268. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9871
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Inhibitory effect of cytochalasins on the motility of rat epididymal spermatozoa in vitro
Cytochalasins, A, B, C, D and E at a concentration of 5.0 μg/ml significantly inhibited the motility of spermatozoa collected from the cauda epididymidis of rats when diluted in Hank's solution containing BSA by 21.6-38.1% within a few min incubation. The motility was significantly inhibited (approx. 16.7%) by Cyto. E at a concentration as low as 1.0 μg/ml within 30 min. This inhibitory effect of Cyto. E was a dose-dependent at the concentrations ranging from 1.0-20.0 μg/ml. These findings demonstrate that cytochalasins are powerful inhibitors on the motility of rat epididymal spermatozoa.
