Publication: Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w
Issued Date
2006-10-01
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ISSN
10902449
00144894
00144894
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2-s2.0-33748521844
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental Parasitology. Vol.114, No.2 (2006), 126-128
Suggested Citation
Thanat Chookajorn, Daniel L. Hartl Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w. Experimental Parasitology. Vol.114, No.2 (2006), 126-128. doi:10.1016/j.exppara.2006.02.019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23302
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Title
Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w
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Abstract
Several genes of Plasmodium falciparum are positively selected due to the pressure from the host immune system. This is a pattern completely opposite to that found in most housekeeping genes, which have few synonymous mutations. The discrepancy is an important topic in Plasmodium biology. We searched for unique polymorphism patterns in P. falciparum and identified a repetitive Stuttering motif in PFI1780w which was recently grouped as a gene in the PHIST family. The repeat has a position-specific polymorphism pattern in the otherwise highly conserved gene. Its mutations are limited to only one small region, and they are not consistent with replication slippage or gene conversion commonly found in low complexity regions. The repeat variation was analyzed in different strains of P. falciparum. The PFI1780w Stuttering motif can be a model to study gene diversification and used as a tool for strain typing. © 2006 Elsevier Inc. All rights reserved.