Publication: Increased blood oxidative stress in amphetamine users
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Issued Date
2010-01-01
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ISSN
13691600
13556215
13556215
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2-s2.0-71949105326
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Mahidol University
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SCOPUS
Bibliographic Citation
Addiction Biology. Vol.15, No.1 (2010), 100-102
Suggested Citation
Piyarat Govitrapong, Parichart Boontem, Patcharee Kooncumchoo, Sirinthorn Pinweha, Jatuporn Namyen, Yupin Sanvarinda, Smith Vatanatunyakum Increased blood oxidative stress in amphetamine users. Addiction Biology. Vol.15, No.1 (2010), 100-102. doi:10.1111/j.1369-1600.2009.00176.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29867
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Title
Increased blood oxidative stress in amphetamine users
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Abstract
Amphetamine derivatives have been shown to be a potential brain neurotoxin based on the production of free radicals that occurs after administration. The purpose of this study was to examine the lipid peroxidation and antioxidant enzymes in the blood of amphetamine users. The plasma lipid peroxidation was determined and reported as thiobarbituric acid reactive substance and was significantly increased (+21%), whereas the activities of the erythrocyte antioxidant enzymes glutathione peroxidase, catalase, and superoxide dismutase were significantly decreased (-32%, -14% and -31%, respectively) in amphetamine users. These results implicated the potential role of oxidative stress in amphetamine-induced neurotoxicity. © 2009 Society for the Study of Addiction.