Publication: Components of the COPD assessment test (CAT) associated with a diagnosis of COPD in a random population sample
Issued Date
2012-04-01
Resource Type
ISSN
15412563
15412555
15412555
Other identifier(s)
2-s2.0-84859322792
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Mahidol University
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SCOPUS
Bibliographic Citation
COPD: Journal of Chronic Obstructive Pulmonary Disease. Vol.9, No.2 (2012), 175-183
Suggested Citation
Natya Raghavan, Yuk Miu Lam, Katherine A. Webb, Jordan A. Guenette, Naparat Amornputtisathaporn, Ramya Raghavan, Wan C. Tan, Jean Bourbeau, Denis E. O'Donnell Components of the COPD assessment test (CAT) associated with a diagnosis of COPD in a random population sample. COPD: Journal of Chronic Obstructive Pulmonary Disease. Vol.9, No.2 (2012), 175-183. doi:10.3109/15412555.2011.650802 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14884
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Title
Components of the COPD assessment test (CAT) associated with a diagnosis of COPD in a random population sample
Abstract
The aim of this study was to determine if components of the COPD Assessment Test (CAT), a validated health status impairment instrument, had additional utility in identifying patients at risk for COPD in whom spirometry testing is appropriate. This study was part of the Canadian Obstructive Lung Disease prevalence study. Consenting participants ≥ 40 years of age were identified by random digit dialing. Smoking history, 8-item CAT scores, and post-bronchodilator spirometry were recorded for each. Stepwise logistic regression analysis was used to identify variables related to the presence of airway obstruction and a final logistic model was developed which best predicted COPD in this sample. Of the 801 individuals approached, 532 were included: 51 (9.6%) had COPD, the majority (92%) of whom fit GOLD I or II severity criteria. Items that correlated significantly with a COPD diagnosis included the CAT total score (p = 0.01) and its breathlessness (p < 0.0001) and phlegm (p = 0.001) components. The final logistic model included: age ( < 55 or ≥55 years), smoking status (current, former, never) and the CAT breathlessness score (ordinal scale 05). The area under the receiver-operating characteristic curve for this model was 0.77, sensitivity was 77.6%, specificity was 64.9% and the positive likelihood ratio was 2.21. In summary, the triad of smoking history, age at least 55 years and the presence of exertional breathlessness were key elements of a simple model which had reliable measurement properties when tested in a random population. This may help identify patients at risk for COPD for whom spirometry testing is recommended. © 2012 Informa Healthcare USA, Inc.