Publication: Phase II study of concurrent chemoradiotherapy for inoperable (Bulky) stage III (A/B) Non-Small Cell Lung Cancer (NSCLC) : A preliminary report
Issued Date
2000-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0034012127
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.83, No.1 (2000), 85-92
Suggested Citation
Vorachai Ratanatharathorn, Puangthong Kraipiboon, Savitree Maoleekoonpairoj, Arkom Cheirsilpa, Vichien Srimuninnimit, Prasert Lertsanguansinchai, Vicharn Lorvidhaya, Ekaphop Sirachainan, Pramook Phromratanapongse, Saipin Tangkaratt, Pitayapoon Pattaranutaporn Phase II study of concurrent chemoradiotherapy for inoperable (Bulky) stage III (A/B) Non-Small Cell Lung Cancer (NSCLC) : A preliminary report. Journal of the Medical Association of Thailand. Vol.83, No.1 (2000), 85-92. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26350
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Title
Phase II study of concurrent chemoradiotherapy for inoperable (Bulky) stage III (A/B) Non-Small Cell Lung Cancer (NSCLC) : A preliminary report
Abstract
We designed a phase II study to determine the feasibility and toxicity of concomitant radiotherapy and Paclitaxel/Carboplatin followed by adjuvant chemotherapy of the same regimen in patients with newly diagnosed inoperable stage III A/B non-small cell lung cancer. Patients were irradiated with a total dose of 66 Gy. Weekly courses of Paclitaxel 45 mg/m2 and Carboplatin AUC 2 were administered intravenously during the irradiation period. After completion of concurrent chemoradiotherapy, adjuvant chemotherapy with Paclitaxel 175 mg/m2 and Carboplatin AUC 6 intravenously every 3 weeks for 4 cycles were given. Since March 1998, 15 patients have been enrolled. All patients were assessable for efficacy and toxicity after concurrent chemoradiotherapy. Eleven patients were assessable for efficacy and toxicity after adjuvant chemotherapy. After concomitant chemoradiotherapy, complete response (CR) was documented in 2 of 15 (13%). Partial response (PR) was documented in 9 of 15 (60%). After completion of adjuvant chemotherapy in 11 patients, the overall response rate was 91 per cent. (18% CR, 73% PR). There were 8 per cent gr. 3-4 neutropenia which occurred during adjuvant chemotherapy. Concomitant Paclitaxel/Carboplatin and radiotherapy are promising modalities in the treatment of inoperable stage III A/B non-small cell lung cancer.