Publication: Observation of genotype C infected chronic hepatitis B patients in clinical practice
Issued Date
2011-01-01
Resource Type
ISSN
19722680
20366590
20366590
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2-s2.0-83755186376
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infection in Developing Countries. Vol.5, No.12 (2011), 882-889
Suggested Citation
Myo Nyein Aung, Wattana Leowattana, Noppadon Tangpukdee, Chatporn Kittitrakul Observation of genotype C infected chronic hepatitis B patients in clinical practice. Journal of Infection in Developing Countries. Vol.5, No.12 (2011), 882-889. doi:10.3855/jidc.1480 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12097
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Title
Observation of genotype C infected chronic hepatitis B patients in clinical practice
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Abstract
Introduction: Hepatitis B virus (HBV) genotype C is prevalent in many areas of the world including Thailand and Southeast Asia. It is a strong risk for hepatocellular carcinoma (HCC) by evidence. We aimed to describe the baseline clinical information of treatment naïve genotype C infected chronic hepatitis B (CHB) patients and to describe the treatment response by surrogate outcome markers in genotype C infected CHB patients after one year of nucleos(t)ide analogues (NA) treatment Methodology: Thirty-four genotype C CHB patients were studied at the Hospital for Tropical Diseases, Bangkok, including 12 patients treated with lamivudine, 11 with telbivudine, 8 with adefovir, and 3 with entecavir. Serum HBV DNA levels, serum alanine amino transferase (ALT) levels, HBeAg status, and alpha-feto protein (AFP) levels were recorded at the start and after twelve months of ongoing treatment. HBV genotyping was performed by line-probe assay. Results: About half of the patients (58.8%) were HBeAg positive. Mean HBV viral load was 6.53 ± 1.15 log 10 copies per ml at baseline and reduced to 3.63 ± 1.3 log10 copies per ml after one year of NA treatment. Serum HBV DNA levels became undetectable in 47.1% of the patients and serum ALT was normalized in 23.5% of the patients. Conclusion: Most of the genotype C patients were aged above 40 years. More than half of the genotype C infected patients did not achieve virological response and biochemical remission. Among the CHB patients, genotype C infected patients are a high priority group for intervention. © 2011 Aung et al.