Publication: Topical 100% serum eye drops for treating corneal epithelial defect after ocular surgery
Issued Date
2013-09-03
Resource Type
ISSN
23146141
23146133
23146133
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2-s2.0-84883149176
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Mahidol University
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SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2013, (2013)
Suggested Citation
Kaevalin Lekhanont, Passara Jongkhajornpong, Lulin Choubtum, Varintorn Chuckpaiwong Topical 100% serum eye drops for treating corneal epithelial defect after ocular surgery. BioMed Research International. Vol.2013, (2013). doi:10.1155/2013/521315 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31220
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Title
Topical 100% serum eye drops for treating corneal epithelial defect after ocular surgery
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Abstract
The purpose of this study was to investigate the efficacy and safety of topical 100% serum eye drops for corneal epithelial defect after ocular surgery. A total of 181 patients who received topical 100% serum therapy for the treatment of corneal epithelial defect following several different types of ocular surgery were recruited into this study. Each patient already failed conventional medical therapy before being prescribed 100% serum eye drops. Slit-lamp biomicroscopic examination with fluorescein staining was performed at baseline and all follow-up visits. The main outcome measures were the rate of complete healing of the corneal epithelial defect and incidence of adverse events. One hundred and seventy-eight eyes (98.34%) received autologous serum eye drops, and 3 (1.66%) received allogeneic serum eye drops. The overall success rate of treating persistent postoperative epithelial defect using 100% serum eye drops was 93.92% (95% CI 0.88-0.98). The median time to complete corneal epithelialization was 4 days (95% CI 4-5). Adverse reactions were observed in 3 patients (1.66%), including sticky sensation with minimal eye discomfort and asymptomatic trace corneal subepithelial infiltration. No serious complications were reported. In conclusion, 100% serum eye drops are effective, safe, and tolerable for treating postoperative corneal epithelial defect following ocular surgeries. © 2013 Kaevalin Lekhanont et al.