Publication: Antigen-specific suppression of inflammatory arthritis using liposomes
Issued Date
2009-03-15
Resource Type
ISSN
15506606
00221767
00221767
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2-s2.0-65449183747
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Immunology. Vol.182, No.6 (2009), 3556-3565
Suggested Citation
Christelle Capini, Montree Jaturanpinyo, Hsin I. Chang, Srinivas Mutalik, Alice McNally, Shayna Street, Raymond Steptoe, Brendan O'Sullivan, Nigel Davies, Ranjeny Thomas Antigen-specific suppression of inflammatory arthritis using liposomes. Journal of Immunology. Vol.182, No.6 (2009), 3556-3565. doi:10.4049/jimmunol.0802972 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27728
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Title
Antigen-specific suppression of inflammatory arthritis using liposomes
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Abstract
Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with Ag (OVA or methylated BSA) and a lipophilic NF-κB inhibitor (curcumin, quercetin, or Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. We injected loaded liposomes into mice primed with Ag or into mice suffering from Ag-induced inflammatory arthritis. The liposomes targeted APCs in situ, suppressing the cells' responsiveness to NF-κB and inducing Ag-specific FoxP3+regulatory T cells. This regulatory mechanism suppressed effector T cell responses and the clinical signs of fullblown Ag-induced arthritis. Thus, liposomes encapsulate Ags and NF-κB inhibitors stably and efficiently and could be readily adapted to deliver Ags and inhibitors for Ag-specific suppression of other autoimmune and allergic diseases. Copyright © 2009 by The American Association of Immunologists, Inc.