Publication: Proteomics in psoriasis
Issued Date
2019-03-01
Resource Type
ISSN
14220067
16616596
16616596
Other identifier(s)
2-s2.0-85062599627
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences. Vol.20, No.5 (2019)
Suggested Citation
Leena Chularojanamontri, Norramon Charoenpipatsin, Narumol Silpa Archa, Chanisada Wongpraparut, Visith Thongboonkerd Proteomics in psoriasis. International Journal of Molecular Sciences. Vol.20, No.5 (2019). doi:10.3390/ijms20051141 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50238
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Title
Proteomics in psoriasis
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Abstract
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Psoriasis has been thought to be driven primarily by innate and adaptive immune systems that can be modified by genetic and environmental factors. Complex interplay between inflammatory cytokines and T-cells, especially Th1 and Th17 cells, leads to abnormal cell proliferation and psoriatic skin lesions. Nevertheless, such mechanisms do not entirely represent the pathogenesis of psoriasis. Moreover, earlier and better biomarkers in diagnostics, prognostics, and monitoring therapeutic outcomes of psoriasis are still needed. During the last two decades, proteomics (a systematic analysis of proteins for their identities, quantities, and functions) has been widely employed to psoriatic research. This review summarizes and discusses all of the previous studies that applied various modalities of proteomics technologies to psoriatic skin disease. The data obtained from such studies have led to (i) novel mechanisms and new hypotheses of the disease pathogenesis; (ii) biomarker discovery for diagnostics and prognostics; and (iii) proteome profiling for monitoring treatment efficacy and drug-induced toxicities.