Publication: Acute Symptoms of Drug Hypersensitivity (Urticaria, Angioedema, Anaphylaxis, Anaphylactic Shock)
8
Issued Date
2010-07-01
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ISSN
00257125
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2-s2.0-77953680578
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Mahidol University
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SCOPUS
Bibliographic Citation
Medical Clinics of North America. Vol.94, No.4 (2010), 691-710
Suggested Citation
Ticha Limsuwan, Pascal Demoly Acute Symptoms of Drug Hypersensitivity (Urticaria, Angioedema, Anaphylaxis, Anaphylactic Shock). Medical Clinics of North America. Vol.94, No.4 (2010), 691-710. doi:10.1016/j.mcna.2010.03.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29609
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Title
Acute Symptoms of Drug Hypersensitivity (Urticaria, Angioedema, Anaphylaxis, Anaphylactic Shock)
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Abstract
Drug hypersensitivity reactions (HSRs) are the adverse effects of drugs which, when taken at doses generally tolerated by normal subjects, clinically resemble allergy. Immediate-reaction of drug HSRs are those that occur less than 1 hour after the last drug intake, usually in the form of urticaria, angioedema, rhinitis, conjunctivitis, bronchospasm, and anaphylaxis or anaphylactic shock. Acute urticarial and angioedema reactions are common clinical problems frequently encountered by internists and general practitioners. They are not specific to drug allergic reaction, and can be caused by various pathogenic mechanisms. Despite the benign course of urticaria and angioedema, a mucocutaneous swelling of the upper respiratory tract could be life-threatening by itself or a feature of anaphylaxis. This article reviews acute symptoms of drug HSR-related urticaria, angioedema, anaphylaxis, and anaphylactic shock, and how clinicians should approach these problems. © 2010 Elsevier Inc. All rights reserved.