Publication: Serum Immunoglobulins in Leprosy Patients with Different Spectra of Clinical Manifestations
Issued Date
1972-01-01
Resource Type
ISSN
15353699
00379727
00379727
Other identifier(s)
2-s2.0-0015369528
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Mahidol University
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SCOPUS
Bibliographic Citation
Proceedings of the Society for Experimental Biology and Medicine. Vol.140, No.3 (1972), 1062-1068
Suggested Citation
Stitaya Sirisinha, Chinda Charupatana, Teera Ramasoota Serum Immunoglobulins in Leprosy Patients with Different Spectra of Clinical Manifestations. Proceedings of the Society for Experimental Biology and Medicine. Vol.140, No.3 (1972), 1062-1068. doi:10.3181/00379727-140-36612 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10005
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Title
Serum Immunoglobulins in Leprosy Patients with Different Spectra of Clinical Manifestations
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Abstract
The concentrations of serum immunoglobulins G, A, M and D from 125 patients with leprosy (40 tuberculoid, 79 lepromatous, and 6 borderline cases) were quantitated by the radial immunodiffusion technique; elevation of IgE in these sera was qualitatively detected by the Ouchterlony technique. The results were analyzed with respect to the type, the duration, and the progress of the disease. The mean levels of IgG, IgA, IgM and IgD were 2171, 539, 148, and 9.9 mg/100 ml, respectively (the corresponding levels in the normal controls were 1480, 282, 126, and 3.7 mg/100 ml). The immunoglobulin alterations were similar in patients with lepromatous and tuberculoid types of disease. Only the increase of IgA seemed to be correlated with the duration of infection, i.e., higher IgA levels were associated with longer duration of infection. Patients who had apparently recovered after drug therapy had higher IgA level, but less IgM than patients with active disease. © 1972, SAGE Publications. All rights reserved.