Chronic renal failure is a common disease in elder dogs. The degeneration of nephron is one of the causes
of this disease, which leads to the end-stage renal failure. Hypertension in chronic renal failure is engendered by
the destruction of that nephron results in the reduction of renal function, and following by the induction of
renin angiotensin aldosterone system as well as inflammatory cytokines. The objective of this review is to
evaluate and describe the use of omega-3 polyunsaturated fatty acids (n-3 PUFA) for reducing hypertension
in chronic renal failure dogs. The supplement of n-3 PUFA leads to changing of eicosanoids synthesis (e.g.
prostaglandins, thrombaxanes, and leukotrienes) to other derivatives, which induce vasodilation and reduce the
inflammation-mediated destruction of glomerulus. For that reason, the omega-3 polyunsaturated fatty
acids supplemenation is an alternative treatment for reducing hypertension in chronic renal failure dogs.
