Publication: Effect of omega-3 polyunsaturated fatty acids supplementation on reducing hypertension in chronic renal failure dogs
8
Issued Date
2008
Resource Type
Language
eng
ISSN
1906-2257
Rights
Mahidol University
Rights Holder(s)
Faculty of Veterinary Science Mahidol University
Bibliographic Citation
Journal of Applied Animal Science. Vol.1, No.1 (2008), 9-18
Suggested Citation
Aekarin Sae-thang, Rungrote Osathanon Effect of omega-3 polyunsaturated fatty acids supplementation on reducing hypertension in chronic renal failure dogs. Journal of Applied Animal Science. Vol.1, No.1 (2008), 9-18. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10094
Research Projects
Organizational Units
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Journal Issue
JAAS Vol. 1 No. 1
(2551)
Thesis
Title
Effect of omega-3 polyunsaturated fatty acids supplementation on reducing hypertension in chronic renal failure dogs
Author(s)
Other Contributor(s)
Abstract
Chronic renal failure is a common disease in elder dogs. The degeneration of nephron is one of the causes
of this disease, which leads to the end-stage renal failure. Hypertension in chronic renal failure is engendered by
the destruction of that nephron results in the reduction of renal function, and following by the induction of
renin angiotensin aldosterone system as well as inflammatory cytokines. The objective of this review is to
evaluate and describe the use of omega-3 polyunsaturated fatty acids (n-3 PUFA) for reducing hypertension
in chronic renal failure dogs. The supplement of n-3 PUFA leads to changing of eicosanoids synthesis (e.g.
prostaglandins, thrombaxanes, and leukotrienes) to other derivatives, which induce vasodilation and reduce the
inflammation-mediated destruction of glomerulus. For that reason, the omega-3 polyunsaturated fatty
acids supplemenation is an alternative treatment for reducing hypertension in chronic renal failure dogs.