Effect of omega-3 polyunsaturated fatty acids supplementation on reducing hypertension in chronic renal failure dogs

Abstract

Chronic renal failure is a common disease in elder dogs. The degeneration of nephron is one of the causes of this disease, which leads to the end-stage renal failure. Hypertension in chronic renal failure is engendered by the destruction of that nephron results in the reduction of renal function, and following by the induction of renin angiotensin aldosterone system as well as inflammatory cytokines. The objective of this review is to evaluate and describe the use of omega-3 polyunsaturated fatty acids (n-3 PUFA) for reducing hypertension in chronic renal failure dogs. The supplement of n-3 PUFA leads to changing of eicosanoids synthesis (e.g. prostaglandins, thrombaxanes, and leukotrienes) to other derivatives, which induce vasodilation and reduce the inflammation-mediated destruction of glomerulus. For that reason, the omega-3 polyunsaturated fatty acids supplemenation is an alternative treatment for reducing hypertension in chronic renal failure dogs.