Publication: Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens
Issued Date
2016-01-01
Resource Type
ISSN
23146141
23146133
23146133
Other identifier(s)
2-s2.0-84971342940
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Mahidol University
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SCOPUS
Bibliographic Citation
BioMed Research International. Vol.2016, (2016)
Suggested Citation
Sirijan Santajit, Nitaya Indrawattana Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens. BioMed Research International. Vol.2016, (2016). doi:10.1155/2016/2475067 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43184
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Title
Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens
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Abstract
© 2016 Sirijan Santajit and Nitaya Indrawattana. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens.