Publication: Electron microscopy of the human brain in cerebral malaria
Issued Date
1985-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0022388109
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.2 (1985), 219-227
Suggested Citation
E. Pongponratn, M. Riganti, T. Harinasuta, D. Bunnag Electron microscopy of the human brain in cerebral malaria. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.2 (1985), 219-227. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30836
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Title
Electron microscopy of the human brain in cerebral malaria
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Abstract
Ultrastructure of erythrocytes infected with Plasmodium falciparum in human brain, obtained 3 hours post mortem revealed gross distortion of host red cells with abnormality of the red cell surface. The superficial alterations of the parasitized cells as knob-like protrusions appear to be the sites of attachment to vascular endothelium. There was evidence of platelets sticking to the injured endothelium. The endothelial vesicular membrane is in close adhesion to the parasitized red cell, and also to the platelets involved in this mechanism, explaining the sequestration of parasitized red cell and obstruction in cerebral microcirculation, cerebral oedema and low peripheral platelet count. There was no evidence of inflammation, fibrin or thrombus formation observed in our studies.